General
Preferred name
SEW-2871
Synonyms
SEW 2871 ()
CHEMBL224720 ()
SEW2871 ()
SEW?2871 ()
SEW2871 ()
P&D ID
PD015662
CAS
256414-75-2
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
calculated probe
experimental probe
P&D approved
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
4
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer¡¯s disease, liver fibrosis, and inflammatory responses[1][2].
PRICE
236
MOA
Agonist
(Chemical Probes.org)
DESCRIPTION
Cell-permeable, selective S1P1 receptor agonist
(Tocriscreen Total)
DESCRIPTION
Silent antagonist for putative abnormal-CBD (Cat. No. 1297) receptor
(Tocris Bioactive Compound Library)
DESCRIPTION
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
Axon Medchem Screening Library
Cayman Chemical Bioactives
Chemical Probes.org
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
440.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
4
cLogP
7.17
TPSA
38.92
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Sphingosine 1-phosphate receptor Edg-1
S1PR1
Akt
ERK
LPL Receptor
LPL
S1P1
Pathway
GPCR/G protein
MAPK/ERK Pathway
PI3K/Akt/mTOR
Stem Cell/Wnt
Primary Target
Sphingosine-1-Phosphate Receptors
MOA
Agonist
Lysophospholipid edg1 (S1P1) Receptor Agonists
S1PR1 agonist
lysophospholipid receptor agonist
Member status
member
Target class
GPCR
Target subclass
Sphingosine receptor
Recommended Cell Concentration
10 uM
Source data
